Laron Syndrome – From Man to Mouse: Lessons from Clinical and Experimental Experience eBook

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Laron Syndrome – From Man to Mouse
Lessons from Clinical and Experimental Experience
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

This is a digital product.

Laron Syndrome – From Man to Mouse: Lessons from Clinical and Experimental Experience 1st Edition is written by Zvi Laron; ‎J. Kopchick and published by Springer. The Digital and eTextbook ISBNs for Laron Syndrome – From Man to Mouse are 9783642111839, 3642111831 and the print ISBNs are 9783642111822, 3642111823.